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Compulsive fiddling with your mask? It does not matter how many lives will be saved. The race to find covid-19 drug treatments that actually work, The antimalarial drug Trump took for covid might actually be dangerous. For example, tylenol+caffeine+fluvoxamine can lead to serotonin syndrome. We report a real-world experience using fluvoxamine for coronavirus disease 19 (COVID-19) in a prospective cohort in the setting of a mass outbreak. This looks ominous, but it harmless. My favorite dosage is 50mg twice a day for 14 days. Over the next few years, millions of unvaccinated people are going to get covid; its vital to try to mitigate their suffering, as well as lessen pressure on the health care system. Some are views most scientists think are wrong. Fluvoxamine public data repository - Google Drive, On Cytokines, Fluvoxamine and COVID-19 Part 1, Jon-Emile S. Kenny MD[@heart_lung] You see, we have a kind of allergy to the past; its our national disease, and the very assurance with which you insist that the past is within the present is l, On Cytokines, Fluvoxamine and COVID-19 Part 2, Jon-Emile S. Kenny MD[@heart_lung] Apocalypse is played out now on a personal scale; it is not in the sky above us, but in our bed. -Mark Doty Introduction With a proposed pathway coupling patho, Effect of Fluvoxamine vs Placebo on Clinical Deterioration in Outpatients With Symptomatic COVID-19, This randomized trial compares the effects of fluvoxamine, a selective serotonin reuptake inhibitor with immunomodulatory effects vs placebo on a composite of dyspnea or pneumonia and oxygen desaturation among adult outpatients with polymerase chain reactionconfirmed mild coronavirus disease 2019 (, Prospective cohort of fluvoxamine for early treatment of COVID-19, Abstract. Get your prescription in advance of getting COVID. You can use fluoxetine as well (aka Prozac). But the confusion provided a fertile breeding ground for skeptics. Their willingness to lie did. All have had a 100% success record in keeping their patients out of the hospital. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. Now they turn to Rust. Dosing. It could do nothing. I must admit that this is an anniversary that snuck Three of the four outpatient trials have been reported out: all were successful. We look for advances that will have a big impact on our lives and break down why they matter. With covid, 80% of your patient population does just peachy with no treatment at all, just a little bed rest and fluid. . It doesnt get much better than that. People are dying because of physician fear of a new treatment with a 100% success rate and a solid mechanism of action. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. Former Silicon Valley tech executive Steve Kirsch, a philanthropist and Substack author who created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs, including fluvoxamine, which reduces death from COVID by a factor of 12. Press - treatearly.org So you can address your OCD and if you get COVID, youll can up the dose. Author Affiliations . Ive used it personally at 50mg twice a day and experience no adverse events at all. It was tested in coronavirus patients because fluvoxamine has very strong anti-inflammatory properties. Still, in the moment, his question threw me, and I stuttered. But Kirsch is also motivated by an unsatisfied competitive streak. Note that some of these articles are inaccurate. Hes refused to accept the results of a hydroxychloroquine trial that showed the drug had no value in treating covid, for instance, instead blaming investigators for poor study design and statistical errors. Also, for people who cant tolerate fluvoxamine for whatever reason (nausea, jittery, etc), this is the alternative. And that is what has allowed Kirsch, and people like him, to become so influential. . Talking to Kirsch is an exhausting experience. Jan 17. For example, tylenol+caffeine+fluvoxamine can lead to serotonin syndrome. Those days are gone. If not, they should at least acknowledge that fluvoxamine might be helpful by at least listing it as a possibility. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. Infoseek lost out to Yahoo; it had a chance to grow bigger, but it didn't. This looks ominous, but it harmless. The premise made sense: Most experts were predicting vaccines would take years, while finding helpful drugs with known safety profiles could shortcut the approval process. They knew in advance it was coming and on the day the paper was published they ignored it entirely. Hes very convincing. His foundation shifted focus to one goalcuring Steve Kirschby supporting one of the few scientists looking at the disease. By Steve Kirsch Last updated: March 14, 2021 After I appeared on the60 Mi nut es story about fluvoxamine,I've received a lot of questions from people about how to treat COVID. But while this effort was praiseworthy, Kirsch's predilection for oversimplifying and exaggerating led him to mislead. Completely avoid caffeine, alcohol, tylenol, and benadryl. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. of the 'intellectual dark web '" and allowed him to access a "large and receptive audience to his claims about a fluvoxamine conspiracy". 4000fluvoxamine750 Proven in clinical use all over the world. Doing something is better than nothing. So the drug had no chance of working (since there were no events), so the trial was stopped for futility, NOT because the drug doesnt work. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. Waiting months for the phase 3 trial to complete is nuts. fluvoxamine The fast, easy, safe, simple, low cost treatment for COVID that has worked 100% of the time to prevent hospitalization that nobody wants to talk about We now have a viable solution to reduce COVID hospitalization and mortality; Read More fluvoxamine Got COVID? Their willingness to lie did. It was completed in August. Should you get vaccinated? Steve Kirsch | TrialSite News And FrameMaker is still a niche product. The Wall Street Journal thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). While Kirsch had the final say in who received grants, no one I spoke with expressed concerns about what projects had been funded, or why. It has shown to be 100% protective of hospitalization in 2 clinical trials. . Be warned!. Some people report mild nausea while on the drug (stops when stop the drug). Molnupiravir followed patients for only 30 days because they know the drug is dangerous. Late in the session, minutes before this impromptu video wrap up, Tip o' Spear Steve Kirsch addressed the panel and revealed that the FDA had just shot down Fluvoxamine as an approved COVID treatment. This advice is now outdated. Hes also recently increased the number of Americans he claim have been killed by the vaccine from 25,0000, to 150,000, or even as many as 250,000 Americans. Finally! Vaccine Depopulation Agenda "Confirmed"? Spike Protein Attack Online. Steve calls himself a "medical philanthropist" who says "the most important thing to me is saving lives." In . In November, CETF gave the group an additional $500,000 for a phase 3 clinical trial that might show conclusive proof of efficacy. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. In 2013, Johnson & Johnson paid $2.2 billion for its own kickback and fraud scandal, including a specific $400 million fine for its subsidiary Janssen, which manufactures the covid vaccine. In short, a lot of mumbo jumbo. Over the last 18 months, the fund has granted at least $4.5 million to researchers testing the covid-fighting powers of drugs that are already FDA-approved for other diseases. Online Status. Once the Phase 2 result came out, it should have been embraced by doctors. This is the gold standard of evidence based medicine. If you cant lay off the java, then try fluoxetine (Prozac). Steve wanted to say, Look, Ive got all these famous [infectious disease] docs and researchers, and they all say give fluvoxamine a chance, Judith Feinberg, one of the former CETF advisory board members and vice chair of research at the West Virginia University School of Medicine, told me. What has alarmed many of the scientists associated with CETF, though, are Kirschs reactions to the work hes fundedboth successes and failures. He pushes fluvoxamine, an anti-depression drug which despite doing very well in covid treatment studies has been strangely neglected. Steve Kirsch (@stkirsch) / Twitter - Twitter. It's what's happening Steve Kirsch: Vaccine Killing Millions, Treatments, VAERS, 5-Month The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. Should Steve Kirsch Be Allowed To Speak on Campus about His Eccentric If you cant get a prescription for COVID, then perhaps you have OCD? JAMA Reports Fluvoxamine as Potential Early Treatment for COVID-19 To date, we have heard nothing suggesting the drug doesn't work or could be harmful. There is no evidence fluvoxamine is harmful and led to a worse outcome. Fluvoxamine for COVID: what you need to know - Substack It is currently approved for treatment of depression and obsessive compulsive disorder (OCD). Medium banned him for misinformation. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a "shared decision making" process. They never make things worse so are safe to try. After I ended the Zoom meeting, Satterfield called me to apologize for cutting us off. Im sorry to sound so cynical. This is the #1 ranked best answer to "COVID treatment" on Quora: Presentation on how fear of trying something new is what keeps us shutdown and leads to unnecessary loss of life: The Lenze fluvoxamine RCT that was published in JAMA on November 12, 2020 showed a 100% success rate in preventing hospitalization. But they dont want their names used. Less than a week later, David Seftel read about the Lenze trial, and ignored the JAMA advice. P-value was 10^-14 on that study (done by Dr. Seftel). Mar. Hes probably the closest thing Kirsch has to a nemesis, regularly disputing his assertions in blog posts and private email exchanges with Kirsch and his friends. They left their recommendation of fluvoxamine at NEUTRAL. If you cant lay off the java, then try fluoxetine (Prozac). Fluvoxamine: The evidence - Steve Kirsch Home page NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. saying that the per-protocol analysis was arbitrary and other excuses. While these are stunning results, less than a dozen doctors in the US are prescribing fluvoxamine today. Three of the four outpatient trials have been reported out: all were successful. They were all given the drug soon after symptoms and the placebo group was pure in that they were not taking any COVID drugs. He has made millions from these projects, even if they have not turned him into a household name. Ivermectin and fluvoxamine have been confirmed in Phase 3 trials. Its really, really common for a small effect, something that looks exciting, to be a statistical fluke when you look at a larger population. To scientists, giving fluvoxamine a chance means running a large trialnot giving it to individual patients in the clinic, off-label and outside the context of active data collection and analysis. The NIH wrote a bullshit rejection because the FDA told them not to approve it. Telling the truth, he tweeted. Months later, the site wont disclose how many doses it helped deliveror what it plans to do with user data. . The medical community doesnt care about saving lives. Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. How covid-19 conspiracy videos keep getting millions of views. His appearance on an episode of anti-covid-vaccine, pro-ivermectin pundit Bret Weinsteins DarkHorse podcast, alongside Robert Malone, a prominent source of vaccine misinformation, introduced Kirsch to followers of the intellectual dark web, who have since embraced him as a fellow truth-teller. I took it myself at that dosage and noticed zero side effects. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI), a class of anti-depressants, mostly prescribed for people suffering from an obsessive-compulsive disorder. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. This 1/6 of the dose the FDA has approved for OCD (the labelled indication for fluvoxamine)! The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. He started a new pseudonymous account, @VaccineTruth2, to continue broadcasting messages. Fluvoxamine has a 40 year safety track record. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). Indeed, some of the most prominent people spreading misinformation about ivermectin and vaccines today began by promoting hydroxychloroquineincluding by claiming to debunk Boulwares data analysis. Also, for people who cant tolerate fluvoxamine for whatever reason (nausea, jittery, etc), this is the alternative. Keyword: ivermectin National Patterns in Antidepressant Medication Treatment - Home of JAMA So it was both obvious and convincing the difference between the groups to the workers and the track management. The FDA approved Molnupiravir which was less effective. Can I see your risk-benefit analysis?. Dr. Seftel is an NIH-funded researcher and an NIH reviewer. Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? I fully expected both organizations to do absolutely nothing. . The reason that it isnt used is because the medical community ignores evidence-based medicine principles. Independent appraisal committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes. Unfortunately, as Jeffrey Morris at UPenn points out, public health officials and scientists have done plenty to undermine their own authority, like claiming masks dont work, downplaying the natural immunity conveyed by previous covid infections, and not doing enough public communication about vaccine safety surveillance systems. Here is what, e) which concluded: Under a variety of assumptions, fluvoxamine shows a high probability of preventing hospitalization in outpatients with COVID-19., For more about fluvoxamine (and other SSRIs that work), see, fluvoxamine completed a Phase 3 study showing it works that was published in the Lancet Global Health, NIH basically dismissed the fluvoxamine study as I predicted they would, few people werent afraid of expressing their displeasure, the highly acclaimed Bangladesh mask study showed, Johns Hopkins has incorporated fluvoxamine in their treatment guidelines, Ontario has become the first province to list fluvoxamine as a treatment doctors can consider for patients. This document is a collection of evidence that highlights the glaring errors in our pandemic response. I think we did rigorous reviews of proposals for research.. He said of his study, This is the most extraordinary effect Ive seen in my 25 years practicing medicine.. He might be a good snake oil salesman., I experienced this myself when, on one call, we discussed several studies. P-value was 10^-14 on that study (done by Dr. Vaccine waitlist Dr. B collected data from millions. Why the FDA should grant an EUA for fluvoxamine immediately, Links to evidence about fluvoxamine including the public data repository, Here's the first one: Or just depression about the vaccine mandates? He is very smart, and he knows that he is very smart, and hesometimes he behaves like he thinks hes the smartest guy in the room, whether he is or isnt, he told me. Compulsive hand washing? Fluvoxamine has a systematic review and meta-analysis published in a top medical journal. But an Editor's Note urged physicians to treat this as a hypothesis and not as a basis for clinical decision-making. But the best way to help people is through rigorous trials that show what drugs help which people, and at what doses and timesnot by basing entire protocols on incredibly limited evidence. Ivermectin has a very high quality systematic review, the highest possible level in Evidence Based Medicine. Thanks to the volumes of data and information provided by pharmaceutical companies and regulators, as well as large numbers of trials from independently funded research groups around the world, I now trust that theyre safe for the vast majority of adults. PDF How I would treat COVID - Steve Kirsch NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. Proxalutamide and fluvoxamine pushers and the early treatment grift. All can merit a fluvoxamine prescription based on traditional diagnoses. 90,000 people will die in the next 3 weeks alone if we continue to ignore this drug that has caused no harm. I've asked people, "there's a lot of evidence here it's not just a small phase 2 RCT. The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. The ICER independent review showed fluvoxamine is more effective than Molnupiravir: Read this article I wrote about using fluvoxamine correctly for COVID. Reached by email, the two fluvoxamine investigators denied that there was any effort to suppress their research, and they were cautiously optimistic about their continued study. . As noted before, the repository has a link to the 1 hour serotonin lecture. . Since making a fortune as the founder of Infoseek, an early search engine that was the Google of its day, Kirsch has spent tens of millions of dollars fighting humanitys biggest threats. Its sad, but its true, he told me. So why would we wait when lives are being lost? There are now 5 independent observational studies that show that the drug works (2 in France, 1 in Germany, 2 in the US). Several other trials around the world are in the final stages, too. Steve angrily decried this development as more evidence of FDA corruption. SSRI Antidepressant Fluvoxamine May Be Effective Early Treatments for The NIH Guidelines committee is being very slow to react (we have no idea if they are even considering the drug because nobody is allowed to know that because all their deliberations are kept secret). Dr. Seftel's paper has been accepted for publication and will appear in OFID in early February. Server IP cope with resolved: Yes Http reaction code: 200 Response time: 0.27 sec. Share this post. It was recommended back in January 2021 by a key opinion leader (KOL) panel to be used, but it took a year for the KOL meeting notes to be published because they were rejected by 10 journals. They were giving covid patients the antidepressant fluvoxamine as soon as possible after diagnosis, based on anecdotes about the drug limiting the runaway immune response that causes many severe symptoms. No one has been able to come up with an example where phase 2 + this level of evidence resulted in a failure of Phase 3. Some countries dont have fluvoxamine so this is the alternative. It could do nothing. That study was featured on 60 Minutes. . One is to reduce the threat of nuclear war. I have all of these on hand and I load up on vitamin D3 every day. There are 4 outpatient studies that have been done (2 at WashU (see. Today, we are letting people drown and we are not even telling them there is a life preserver they can ask for today with compelling evidence that is under consideration by the life preserver safety group. Yes, these were successes, but the successes could have been bigger if we had really paid attention to marketing. So how did a man once intent on furthering science become a source of misinformation that undermines the very research he funded? How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. After several failed attempts to stop the progression of his disease, he designed his own protocol for chemotherapy and doctor-shopped to find an oncologist who would give it to him. Quick Summary . It is perhaps the greatest unnecessary loss of life in American history.