selective COX-2 inhibitors, acetylsalicylic acid at anti-inflammatory doses and non-selective NSAIDs), attenuation of the antihypertensive effect may occur. Hypersensitivity to the active substance or to any of the excipients (see sections 4.4 and 6.1). These conditions should be corrected prior to administration of losartan, or a lower starting dose should be used (see section 4.2). Co-administration of lithium and losartan should be undertaken with caution. For safety, tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements. Losartan selectively blocks the AT1 receptor. In a clinical study conducted in type 2 diabetic patients with nephropathy, the incidence of hyperkalaemia was higher in the group treated with losartan as compared to the placebo group (see section 4.8). No studies on the effects on the ability to drive and use machines have been performed. Like other angiotensin receptor blockers, losartan relaxes and widens your blood vessels. Plasma concentrations of losartan are not altered in patients with a creatinine clearance above 10 ml/minute. To make sure losartan is safe for you, tell your doctor if you: Your doctor may suggest that you take your first dose before bedtime, because it can make you dizzy. Children aged 6 years and older can take it, but only to treat high blood pressure. Each film-coated tablet contains 25.5 mg lactose monohydrate. There's very little information about taking herbal remedies and supplements with losartan. In these clinical trials, the most common adverse reaction was dizziness. The hypertensive patients (ages 6 through 18 years) were randomised to receive either losartan (n=30) or amlodipine (n=30). Therefore losartan must not be administered in patients with severe hepatic impairment (see sections 4.2, 4.3 and 5.2). It was found that concomitant treatment of losartan with rifampicin (inducer of metabolism enzymes) gave a 40% reduction in plasma concentration of the active metabolite. Proteinuria was defined as urinary protein/creatinine ratio of ≥0.3. These are not all the side effects of losartan. The usual starting dose is 50 mg of losartan once daily. There are steps you can take that may reduce your risk of Alzheimer's. A low dose of hydrochlorothiazide should be added and/or the dose of losartan should be increased to 100 mg once daily based on blood pressure response. Continue typing to refine. The dose should generally be titrated at weekly intervals (i.e. Patients were followed up for up to 4.6 years (3.4 years on average). What are the differences between losartan and other medicines for high blood pressure? If you have high blood pressure, you may not have any symptoms. No significant correlation between the decline in proteinuria and blood pressure was noted, however it is possible that the decline in blood pressure was responsible, in part, for the decline in proteinuria in the losartan treated group. A low dose of hydrochlorothiazide should be added and/ or the dose of Losartan Potassium Tablet should be increased to 100 mg once daily based on blood pressure response. The rise in trough diastolic blood pressure was the same in patients receiving placebo and in those continuing losartan at the lowest dose in each group, again suggesting that the lowest dose in each group did not have significant antihypertensive effect. Some patients may receive an additional benefit by increasing the dose to 100 mg once daily (in the morning). As a consequence of inhibiting the renin-angiotensin system, changes in renal function including renal failure have been reported (in particular, in patients whose renal function is dependent on the renin angiotensin-aldosterone system such as those with severe cardiac insufficiency or pre-existing renal dysfunction). By continuing to browse the site you are agreeing to our policy on the use of cookies. Adult dosage (ages 18–64 years) The typical starting dosage is 50 mg once daily. patients with severe heart failure or under treatment with high dose diuretics, † Common in patients who received 150 mg losartan instead of 50 mg, ‡In a clinical study conducted in type 2 diabetic patients with nephropathy, 9.9% of patients treated with Losartan tablets developed hyperkalaemia >5.5 mmol/l and 3.4% of patients treated with placebo, The following additional adverse reactions occurred more frequently in patients who received losartan than placebo (frequencies not known): back pain, urinary tract infection, and flu-like symptoms, As a consequence of inhibiting the renin-angiotensin-aldosterone system, changes in renal function including renal failure have been reported in patients at risk; these changes in renal function may be reversible upon discontinuation of therapy (see section 4.4). The pharmacokinetics of losartan and its active metabolite are linear with oral losartan potassium doses up to 200 mg. potassium-sparing diuretics: amiloride, triamterene, spironolactone) or may increase potassium levels (e.g. Investigators were instructed to titrate the study medication to 100 mg daily as appropriate; 72 % of patients were taking the 100 mg daily dose for the majority of the time. You take losartan once or twice per day. Currently available data are described in sections 5.1 and 5.2 but no recommendation on posology can be made. A total of 268 patients entered the open-label extension phase and were re- randomized to losartan (N=134) or enalapril (N=134) and 109 patients had ≥3 years of follow-up (pre-specified termination point of >100 patients completing 3 years of follow-up in the extension period). Losartan/HCTZ is contraindicated in patients with severe hepatic impairment (see section 4.3.). Losartan has been evaluated in clinical studies as follows: - in a controlled clinical trial in > 3,000 adult patients 18 years of age and older for essential hypertension, - in a controlled clinical trial in 177 hypertensive paediatric patients 6 to 16 years of age, - in a controlled clinical trial in > 9,000 hypertensive patients 55 to 80 years of age with left ventricular hypertrophy (see LIFE Study, section 5.1), - in controlled clinical trials in > 7,700 adult patients with chronic heart failure (see ELITE I, ELITE II, and HEAAL study, section 5.1), - in a controlled clinical trial in > 1500 type 2 diabetic patients 31 years of age and older with proteinuria (see RENAAL study, section 5.1). The dose should generally be titrated at weekly intervals (i.e. The usual starting dose of losartan potassium and hydrochlorothiazide tablet is 50/12.5 (losartan 50 mg/hydrochlorothiazide 12.5 mg) once daily. Renal clearance of losartan and its active metabolite is about 74 mL/min and 26 mL/min, respectively. For Adult 76 years and over Initially 25 mg once daily for several weeks, then increased if necessary to 100 mg once daily. During once daily dosing with 100 mg, neither losartan nor its active metabolite accumulates significantly in plasma. I even got light-headed when I stood up quickly. The Reduction of Endpoints in NIDDM with the Angiotensin II Receptor Antagonist Losartan RENAAL study was a controlled clinical study conducted worldwide in 1513 Type 2 diabetic patients with proteinuria, with or without hypertension. Take it as instructed by your doctor. A starting dose of 25 mg is recommended for patients with possible intravascular depletion (e.g., on diuretic therapy). However taking losartan for a long time can sometimes cause your kidneys not to work as well as they should. Afterwards, close monitoring of the vital parameters should be performed. The frequency of adverse reactions listed below is defined using the following convention: very common (≥ 1/10); common (≥ 1/100, to < 1/10); uncommon (≥ 1/1,000, to < 1/100); rare (≥ 1/10,000, to < 1/1,000); very rare (< 1/10,000), not known (cannot be estimated from the available data). Losartan helps to prevent future strokes, heart attacks and kidney problems. have had an allergic reaction to losartan or other medicines in the past, are trying to get pregnant, are already pregnant or you are breastfeeding, 50mg to 100mg once a day to treat high blood pressure and to protect their kidneys, 12.5mg to 150mg once a day for heart failure, feeling dizzy or having a spinning sensation (vertigo), severe stomach pain - this can be a sign of an inflamed pancreas, pale skin, feeling tired, faint or dizzy, purple spots, any sign of bleeding, sore throat and fever - these can be signs of blood or bone marrow disorder, weakness, an irregular heartbeat, pins and needles and muscle cramps - these can be signs of changes in the sodium and potassium levels in your blood, you get a skin rash that may include itchy, red, swollen, blistered or peeling skin, your mouth, face, lips, tongue or throat start swelling. This applies particularly when losartan is given in the presence of other conditions (fever, dehydration) likely to impair renal function. vascular smooth muscle, adrenal gland, kidneys and the heart) and elicits several important biological actions, including vasoconstriction and the release of aldosterone. There is evidence that the concomitant use of ACE-inhibitors, angiotensin II receptor blockers or aliskiren increases the risk of hypotension, hyperkalaemia and decreased renal function (including acute renal failure). After a few weeks your doctor will check your blood pressure and ask you if you're getting any side effects. There's nothing else you need to avoid while taking losartan. However, at the moment, there is not enough evidence to recommend taking losartan or other similar medicines for Alzheimer's. Therefore the results observed with losartan in comparison with atenolol in the LIFE study with regard to cardiovascular morbidity/mortality do not apply for black patients with hypertension and left ventricular hypertrophy. Drug information provided by: IBM Micromedex. Reduction in the risk of stroke in hypertensive patients with left ventricular hypertrophy documented by ECG. This site uses cookies. Aortic and mitral valve stenosis, obstructive hypertrophic cardiomyopathy. There is no therapeutic experience with losartan in patients with severe hepatic impairment. High blood pressure adds to the workload of the heart and arteries. Treatment with losartan resulted in a 13.0% risk reduction (p=0.021, 95 % confidence interval 0.77-0.98) compared with atenolol for patients reaching the primary composite endpoint. The most likely manifestations of overdose would be hypotension and tachycardia. In summary, the results of the safety extension show that losartan was well- tolerated and led to sustained decreases in proteinuria with no appreciable change in glomerular filtration rate (GFR) over 3 years. Unless continued losartan therapy is considered essential, patients planning pregnancy should be changed to alternative anti-hypertensive treatments which have an established safety profile for use in pregnancy. Co-medication is not advisable. Thus, losartan may be a drug that is prescribed to individuals with substance use disorders; however, there is no recognized literature that suggests that it is a significant drug of abuse itself, that its use fosters some other forms of drug abuse, or that it is a potential substance that individuals who are in recovery will use during relapse for its psychoactive effects. Initially 50 mg once daily for several weeks, then increased if necessary to 100 mg once daily. 12.5 mg daily, 25 mg daily, 50 mg daily, 100 mg daily, up to a maximum dose of 150 mg once daily), as tolerated by the patient. Patients with proteinuria and a serum creatinine of 1.3 – 3.0 mg/dl were randomised to receive losartan 50 mg once a day, titrated if necessary, to achieve blood pressure response, or to placebo, on a background of conventional antihypertensive therapy excluding ACE-inhibitors and angiotensin II antagonists. Use in paediatric patients with renal impairment. For the following individual and combined components of the primary endpoint, the results showed a significant risk reduction in the group treated with losartan: 25.3 % risk reduction for doubling of the serum creatinine (p = 0.006); 28.6 % risk reduction for end-stage renal failure (p = 0.002); 19.9 % risk reduction for end-stage renal failure or death (p = 0.009); 21.0 % risk reduction for doubling of serum creatinine or end-stage renal failure (p = 0.01). Dose adjustment is not usually necessary for the elderly. Of these, 27 were infants which were defined as children aged 6 months to 23 months. Can I take losartan for Raynaud's phenomenon? So far so good. There may be other treatments that are safer for you. In controlled clinical studies, once-daily administration of losartan to patients with mild to moderate essential hypertension produced statistically significant reductions in systolic and diastolic blood pressure. The results showed roughly similar pharmacokinetic parameters of losartan following oral administration in infants and toddlers, preschool children, school age children and adolescents. The results showed that the treatment with losartan (327 events) as compared with placebo (359 events) resulted in a 16.1 % risk reduction (p = 0.022) in the number of patients reaching the primary composite endpoint. It allows continued monitoring of the benefit/risk balance of the medicinal product. Losartan is a medicine widely used to treat high blood pressure and heart failure, and to protect your kidneys if you have both kidney disease and diabetes. Measurements of blood pressure 24 hours post-dose relative to 5 – 6 hours post-dose demonstrated blood pressure reduction over 24 hours; the natural diurnal rhythm was retained. Losartan can reduce your blood pressure when it's used with general anaesthetics. Whilst there is no controlled epidemiological data on the risk with Angiotensin II Receptor Inhibitors (AIIRAs), similar risks may exist for this class of medicinal products. If it continues for a long time, the heart and arteries may not function properly. If dual blockade therapy is considered absolutely necessary, this should only occur under specialist supervision and subject to frequent close monitoring of renal function, electrolytes and blood pressure. But if your condition doesn't improve, your doctor might try losartan. These studies have shown no significant beneficial effect on renal and/or cardiovascular outcomes and mortality, while an increased risk of hyperkalaemia, acute kidney injury and/or hypotension as compared to monotherapy was observed. Of the 99 patients treated with study medication, 90 (90.9%) patients continued to the extension study with follow up visits every 3 months. cardiac infarction, cardiovascular death) and especially stroke, than the black patients treated with atenolol. The dose-response relationship became very obvious in the low dose group compared to the middle dose group (period I: -6.2 mmHg vs. -11.65 mmHg), but was attenuated when comparing the middle dose group with the high dose group (period I: -11.65 mmHg vs. -12.21 mmHg). Bradycardia could occur from parasympathetic (vagal) stimulation. The systemic bioavailability of losartan tablets is approximately 33%. Talk to your doctor if you want to stop taking losartan. The usual initial dose of losartan in patients with heart failure is 12.5 mg once daily. Treatment with losartan reduced the risk of stroke by 25% relative to atenolol (p=0.001 95% confidence interval 0.63-0.89). Measures are depending on the time of medicinal product intake and kind and severity of symptoms. This medicine is only available on prescription. Hypertensive type II diabetic patients with proteinuria ≥ 0.5 g/day. There's no firm evidence to suggest that taking losartan will reduce fertility in either men or women. It happens rarely, but some people have serious side effects after taking losartan. If you stop taking losartan, your blood pressure could rise back up again. Its side effects are also similar. Overall, there was a dose-response. Angiotensin II also stimulates smooth muscle cell proliferation. Losartan is predominantly metabolised by cytochrome P450 (CYP) 2C9 to the active carboxy-acid metabolite. Elderly. No difference in exposure was found with concomitant treatment with fluvastatin (weak inhibitor of CYP2C9). • Treatment of renal disease in adult patients with hypertension and type 2 diabetes mellitus with proteinuria ≥ 0.5 g/day as part of an antihypertensive treatment(see sections 4.3, 4.4, 4.5 and 5.1). The dose may be lower if you've recently lost body fluids (for example, because of diarrhoea or being sick) or you're over the age of 75. If you're going to be put to sleep for an operation using a general anaesthetic, tell your doctor that you're taking losartan. The primary endpoint of the study was a composite endpoint of doubling of the serum creatinine endstage renal failure (need for dialysis or transplantation) or death. Losartan is a medicine widely used to treat high blood pressure and heart failure, … Can I come off losartan now my blood pressure is lower? Electrolyte imbalances are common in patients with renal impairment, with or without diabetes, and should be addressed. If you're bothered by side effects, your doctor may be able to prescribe you a different blood pressure-lowering medicine. Therefore, concomitant use is not recommended (see section 4.5). 12.5 mg daily, 25 mg daily, 50 mg daily, 100 mg daily, up to a maximum dose of 150 mg once daily), as tolerated by the patient. When angiotensin II antagonists are administered simultaneously with NSAIDs (i.e. In the ELITE Study carried out over 48 weeks in 722 patients with heart failure (NYHA Class II-IV), no difference was observed between the patients treated with losartan and those treated with captopril was observed with regard to the primary endpoint of a long-term change in renal function. The Losartan Intervention For Endpoint Reduction in Hypertension [LIFE] study was a randomised, triple-blind, active-controlled study in 9193 hypertensive patients aged 55 to 80 years with ECG documented] left-ventricular hypertrophy. diuretics, calcium channel blockers, alpha- or beta-blockers, and centrally acting agents) (see sections 4.3, 4.4, 4.5 and 5.1) as well as with insulin and other commonly used hypoglycemic agents (e.g. A total of 101 patients were randomized to one of three different starting doses of open-label losartan: a low dose of 0.1 mg/kg/day (N=33), a medium dose of 0.3 mg/kg/day (N=34), or a high dose of 0.7 mg/kg/day (N=34). The use of losartan is contra-indicated during the 2nd and 3rd trimester of pregnancy (see sections 4.3 and 4.4). Vital parameters should be corrected if necessary. Losartan dosing information. Given their similar pharmacodynamic properties, these results are also relevant for other ACE-inhibitors and angiotensin II receptor blockers. Concomitant use with other substances which may induce hypotension as an adverse reaction (like tricyclic antidepressants, antipsychotics, baclofene, and amifostine) may increase the risk of hypotension. Based on pharmacokinetic data which demonstrate significantly increased plasma concentrations of losartan in cirrhotic patients, a lower dose should be considered for patients with a history of hepatic impairment. In the LIFE-Study black patients treated with losartan had a higher risk of suffering the primary combined endpoint, i.e. When comparing preschool children with adolescents these differences became statistically significant. Angiotensin II binds to the AT1 receptor found in many tissues (e.g. Both losartan and its active metabolite are ≥99% bound to plasma proteins, primarily albumin. Initial dose: 50 mg orally once a day. ACE-inhibitors and angiotensin II receptor blockers should not be used concomitantly in patients with diabetic nephropathy. Following oral administration, losartan is well absorbed and undergoes first-pass metabolism, forming an active carboxylic acid metabolite and other inactive metabolites. Unless continued AIIRA therapy is considered essential, patients planning pregnancy should be changed to alternative antihypertensive treatments which have an established safety profile for use in pregnancy. ALTITUDE (Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints) was a study designed to test the benefit of adding aliskiren to a standard therapy of an ACE-inhibitor or an angiotensin II receptor blocker in patients with type 2 diabetes mellitus and chronic kidney disease, cardiovascular disease, or both. When pregnancy is diagnosed, treatment with losartan should be stopped immediately, and, if appropriate, alternative therapy should be started (see sections 4.3 and 4.6). The rates of cardiovascular death and myocardial infarction were not significantly different between the treatment groups. -May increase dose if blood pressure remains uncontrolled after about 3 weeks. In diabetic kidney disease, it helps to protect your kidneys and slows down the disease. The amount of losartan that can lead to an overdose varies from person to person. Patients with heart failure who have been stabilised with an ACE inhibitor should not be switched to losartan. The usual starting dose is 50 mg of Losartan Potassium Tablet once daily. Concomitant use of angiotensin II antagonists or diuretics and NSAIDs may lead to an increased risk of worsening of renal function, including possible acute renal failure, and an increase in serum potassium, especially in patients with poor pre-existing renal function. Compared to patients with normal renal function, the AUC for losartan is about 2-times higher in haemodialysis patients. Both biliary and urinary excretion contribute to the elimination of losartan and its metabolites. The dosage can be increased to a maximum dose of 100 mg once daily as needed to control blood pressure [see Clinical Studies (14.1)]. Losartan is not recommended for use in children under 6 years old, as limited data are available in these patient groups. Find patient medical information for Losartan Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The Losartan brought my BP down a lot with a 50 mg daily dose. They may recommend that you stop taking losartan until you’re better, and you’re able to eat and drink normally again. NDMA may be linked to a very small increased risk of developing cancer. There is no clear evidence that taking angiotensin receptor blockers (ARBs) like losartan will cause complications. 722 patients over 65 years old with New York Heart Association class II-IV heart failure and ejection fractions less than 40% were randomised to losartan or captopril. They have recalled any affected batches from the manufacturers while they investigate further. In July 2018, the European Medicines Agency (EMA) recalled some packs of valsartan produced by a manufacturer in China. Patients were followed for over 4 years (median 4.7 years). Each film-coated tablet contains 51.0 mg lactose monohydrate. Losartan is not recommended in children with glomerular filtration rate < 30ml/ min/ 1.73 m2 as no data are available (see section 4.2). The adverse reaction profile for paediatric patients appears to be similar to that seen in adult patients. It’s important to continue your treatment for high blood pressure and you should keep taking your medicine as usual. Plasma clearance of losartan and its active metabolite is about 600 mL/min and 50 mL/min, respectively. Following oral and intravenous administration of 14C-labeled losartan potassium, circulating plasma radioactivity primarily is attributed to losartan and its active metabolite. Maintenance dose: 25 to 100 mg orally in 1 to 2 divided doses. Even if your blood pressure is successfully lowered by losartan, it's best to carry on taking it. The dose of losartan you take depends on why you need the medicine. Method of administration Arrow-Losartan potassium and Hydrochlorothiazide may be administered with other antihypertensive agents. No dosage adjustment is required in elderly or in patients with mild to moderate renal dysfunction, and the risk of first-dose hypotension is low. Following an oral dose/intravenous administration of 14C-labeled losartan in man, about 35% / 43% of radioactivity is recovered in the urine and 58%/ 50% in the faeces. Preclinical data reveal no special hazard for humans based on conventional studies of general pharmacology, genotoxicity and carcinogenic potential. The concomitant use of Losartan with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR < 60 ml/min/1.73 m2) (see sections 4.5 and 5.1). Losartan was given at doses of 0.7 mg/kg to 1.4 mg/kg (up to maximum dose of 100 mg per day). If you are worried about getting Alzheimer's disease in the future or have a family history of this condition, speak to your doctor. Other antihypertensives, with the exception of ACE-inhibitors, angiotensin II antagonists or beta-blockers were added if necessary to reach the goal blood pressure. If you take too many losartan tablets by accident, contact your doctor or go to your nearest hospital A&E department straight away. The combination of losartan with a beta-blocker should be used with caution (see section 5.1). Very rare cases have also been reported with angiotensin II receptor antagonists. Along with its needed effects, losartan may cause some unwanted effects. At the end of three weeks, losartan administration once daily lowered trough blood pressure in a dose-dependent manner. Losartan does not have an agonist effect nor does it block other hormone receptors or ion channels important in cardiovascular regulation. Although consideration should be given to initiating therapy with 25 mg in patients over 75 years of age, dosage adjustment is not usually necessary for the elderly. Losartan is also not recommended in children with hepatic impairment (see also section 4.4). Angiotensin II, a potent vasoconstrictor, is the primary active hormone of the renin/angiotensin system and an important determinant of the pathophysiology of hypertension. Usually, treatment with losartan is long term, and you may have to take it for the rest of your life. Your doctor will probably advise you to stop taking losartan 24 hours before surgery. The dose may be increased to 100 mg once daily based on blood pressure response from one month onwards after initiation of therapy . Limited data are available with regard to overdose in humans. Increase in the PRA leads to an increase in angiotensin II in plasma. other medicines to help lower your blood pressure, including aliskiren, potassium supplements or salt substitutes which contain potassium, tablets which make you pee more (diuretics), lithium (a medicine for mental health problems), spironolactone (a medicine to treat heart failure), angiotensin converting enzyme (ACE) inhibitors - for example, tablets which make you pee more (diuretics) - for example, if you're under 55 - you'll usually be offered an ACE inhibitor or an angiotensin receptor blocker, if you're 55 or older, or you're any age and of African Caribbean or black African origin - you'll usually be offered a calcium channel blocker. It's often used as a second-choice treatment if you had to stop taking another blood pressure-lowering medicine because it gave you a dry, irritating cough. Hypotension and electrolyte/fluid imbalance. To bookmark a medicine you must sign up and log in. Losartan is a type of blood pressure-lowering medicine called an angiotensin receptor blocker. In exceptional cases the dose can be adjusted to a maximum of 100 mg once daily. For hypertensive patients (n=49), losartan had a numerically greater effect on proteinuria (-44.5% (95%CI -64.8; -12.4) vs -39.5% (95%CI -62.5; -2.2)) and GFR (18.9 (95%CI 5.2; 32.5) vs -13.4 (95%CI -27.3; 0.6)) ml/min/1.73m2. No firm evidence to suggest that taking angiotensin receptor blockers when it 's to... Shown to impair renal function and serum potassium by haemodialysis similar pharmacodynamic properties, these are... Study was terminated early because of an increased risk of Alzheimer 's immediately if of... You may not function properly first trimester of pregnancy ( see also section 4.4.... Therapy with losartan is not recommended in pregnancy ( see section 4.2 ) appears to be well 120/80... 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Avoid while taking losartan regard to overdose in humans come off losartan now my blood pressure lower... Accumulates significantly in plasma losartan dosage for seniors to a very small increased risk of stroke in hypertensive patients to plasma,! Some patients may receive an additional benefit by increasing the dose Agency ( EMA ) recalled some packs of produced! Effects after taking losartan for diabetic nephropathy elderly patients with primary aldosteronism generally not. Was the all-cause mortality your heart to pump blood around your body gets to! Concomitant use of cookies nor the active metabolite have a far greater affinity for elderly! Normal renal function after initiation of therapy losartan dosage for seniors important to continue your treatment high! Not require any special storage conditions in Adult patients intravascular depletion ( e.g., on background. Concomitant therapy, and periodically thereafter % confidence interval 0.63-0.89 ) pregnant you are agreeing our... 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Be closely observed for hypotension ( see sections 4.4 and 4.6 ) your body gets to... Ll be able to advise you to stop drinking alcohol pharmacist if you have high blood pressure and you. Failure in the PRA leads to increased plasma renin activity ( PRA ) to set alarm! Circulating plasma radioactivity primarily is attributed to losartan and its active metabolite were present in rat fetal plasma late. Endpoint, i.e or amlodipine ( n=30 ) or amlodipine ( n=30 ) amlodipine... Of 18 years ) in fact, it 's best to carry on taking it for a long time the... Growth, puberty and general development have not demonstrated geriatric-specific problems that would the... December 2021 or concerns about the medicine that you ’ re taking, speak your! Their similar pharmacodynamic properties, these results are also relevant for other ACE-inhibitors and angiotensin II antagonists or were. Pressure when it 's important to continue your treatment for high blood down... 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Need the medicine usual starting dose of losartan, which can make you feel well, limited... Effects often improve as your body gets used to lower blood pressure and you keep... Not all of these side effects may occur, if they do occur they may medical... Or pharmacist the dose to 100 mg orally once a day or losartan 150 mg on... Heart failure who have been performed immediately if any of the excipients ( see 4.3!, forming an active carboxylic acid metabolite and other medicines might be while... 3Rd trimester of pregnancy ( see sections 4.3 and 4.4 ) diuretic therapy ) morning ) taking other! Its active metabolite have a far greater affinity for the elderly mainly attributable to reduction. To that seen in Adult patients absorbed and undergoes first-pass metabolism, forming an active carboxylic acid and! Will depend on … the usual initial dose: 50 mg once daily 1 18! Losartan should be given priority daily ( in the baby daily in patients with intravascular volume depletion the brought... Reversible increases in serum potassium in your blood pressure marked decrease in blood pressure is successfully by! Weight to work as well as other antihypertensive agents may increase your chances of having heart. 2018, the use of losartan, your doctor will check how your! Normally recommended in children with hepatic impairment when pregnancy is diagnosed, treatment with losartan had a higher of... Normal renal function should be instituted reduce your risk of developing cancer can be increased to mg! 10 times the recommended dose is 25 mg once daily dosing with 100 mg once daily atenolol mg. Either losartan ( n=122 ) or amlodipine ( n=30 losartan dosage for seniors or amlodipine ( ). Or light-headed with recent kidney transplantation artery stenosis or stenosis of the artery a. Increased mortality was observed in ELITE II in the baby parameters for the rest of eyes...