In 1999, after the appointment of Kenneth Polonsky, MD, as the new Chairman of Medicine, Dr. DiPersio was named Chief, Division of Oncology, which consolidated the Divisions of BMT and Medical Oncology into one division. They established two separate divisions that emerged from the need to expand the clinical activities that were, up until that time, a part of the division of Hematology-Oncology. To understand how patients respond to these drugs, the researchers will implant the patients’ tumors into mice that then will receive the same treatment regimen. By 2010, the SCC had become one of the largest cancer centers in the country, with over 7,000 new cancer patients cared for each year. WU Record 7/29/16, David DeNardo, Andrea Wang-Gillam and their colleagues have shown that immunotherapy against pancreatic cancer can be effective when given in conjunction with focal adhesion kinase (FAK) inhibitors, drugs that break up the fibrous tissue in these tumors. Origins of the Oncology Division The Division of Oncology is the newest division of the Department of Medicine. In the various inpatient and outpatient settings, hematology faculty provide expert primary and consultative care for patients with a diverse spectrum of benign and malignant blood-related disorders. Hematology-Oncology Fellowship Program 660 S Euclid Ave., Campus Box 8056 St. Louis MO 63110 Phone: 314-747-8479 Fax: 314-362-7086 Email: [email protected] ©2021 Washington University in … The Medicine and Cell Biology researchers occupy adjacent space on the fifth floor of the McDonnell Sciences Research Building. Personalized services for cancers and other blood disorders. A small clinical trial conducted by Rizwan Romee and Todd Fehniger provides evidence that the immune system’s "natural killer" cells can be dialed up in the laboratory, trained to recall that activation and then effectively unleashed to destroy cancer cells in some patients. Kornfeld's research has been instrumental in understanding the workings of lysosomal proteins, which must make their way to the cells' lysosomes in order to digest cellular parts and molecules that are no longer needed and help cells dispose of viruses and bacteria. [Text written by John F. DiPersio for the Department of Medicine Centennial Celebration, September, 2010], Hematology Research / Work-in-Progress Seminar, Mechanisms in Cancer Biology Research Forum, K12 Paul Calabresi Career Development Program in Clinical Oncology, T32 Training Program in Molecular Hematology, Adult Hemophilia and Bleeding Disorders Center, Center for Gene and Cellular Immunotherapy, Chief of Hematology (Hanna Khoury, MD, Emory University), Director of Transfusion Medicine (Lawrence Goodnough, MD, Stanford University), Directors of BMT Programs (Steve Devine, MD, Ohio State University, and Randy Brown, MD, University of Kentucky), Director of Institute of Personalized Medicine (Howard McLeod, PhD, University of North Carolina), Director of Institute of Regenerative Medicine (Jan Nolta, PhD, University of California - Davis), Director of Phase I Program (Joanne Mortimer, MD, City of Hope), Deputy Director of Cancer Center (Paula Fracasso, MD, PhD, University of Virginia), Associate Members (James Hseih, MD, PhD, and Emily Cheng, PhD, Memorial Sloan Kettering Cancer Institute), Immunotherapy (Gerald P. Linette, MD, PhD, and Beatriz M. Carreno, PhD), Gene therapy (Mark S. Sands, PhD, and DiPersio), Stem cell-stromal niche interactions (Daniel C. Link, MD), Preleukemic syndromes (Timothy A. Graubert, MD, and Matthew J. Walter, MD), Myeloma biology and genetics (Michael H. Tomasson, MD, Ravi Vij, MD, and Katherine N. Weilbaecher, MD), Transplantation biology and models of graft vs. host disease (DiPersio, Ley, Todd A. Fehniger, MD, PhD, Michael P. Rettig, PhD, and Peter Westervelt, MD, PhD), Osteoblast biology (Weilbaecher, Ratner, Link), HIV and HTLV-associated oncogenesis (Ratner), Ribosomal biogenesis (Jason D. Weber, PhD), T cell and NK cell biology (Ley, Fehniger, Linette and Carreno), Breast cancer signaling and biology (Weilbaecher, Ellis, Loren S. Michel, MD, Ron Bose, MD, PhD, and Cynthia X. Ma, MD, PhD), Experimental therapeutics of solid and “liquid” malignancies (Joel Picus, MD, A. Craig Lockhart, MD, Benjamin R. Tan, Jr., MD, Andrea Wang-Gillam, MD, PhD, Geoffrey L. Uy, MD, Amanda F. Cashen, MD, Ramaswamy Govindan, MD, and Westervelt), Clinical and translational studies in normal and leukemic stem cell trafficking (Link, Rettig, Uy and DiPersio), Novel drugs and approaches to lymphoma patients (Nancy L. Bartlett, MD, Cashen, Nina D. Wagner-Johnston, MD, and Kenneth R. Carson, MD), Cancer and Leukemia Group B (Bartlett, Ellis, Govindan, Picus), American College of Surgeons Oncology Group (Ellis, Govindan), NCI Phase II Consortium (Douglas R. Adkins, MD), BMT Clinical Trials Network (Westervelt, DiPersio), American Society of Hematology (Ley, DiPersio and Link), Leukemia and Lymphoma Society (Graubert and Camille N. Abboud, MD), TCGA (Ley, Graubert, Tomasson, Vij and DiPersio). The division is composed of twenty five attending physician scholars, nine physician fellows, twenty advanced practice nurses, fifteen clinic nurses, and more than 40 research and support staff. Apply to Associate Professor, Assistant Professor, Oncologist and more! Concise, portable, and user-friendly, The Washington Manual Hematology and Oncology Subspecialty Consult, 4th Edition, provides quick access to the essential information needed to evaluate a patient on a subspecialty consult service. Other faculty members, including Elliott E. Abbey, MD, and Scot G. Hickman, MD, developed the Washington University hematology-oncology service at the St. Louis VA Hospital during the 1980s. The Division of Hematology/Oncology is a part of the Washington University Department of Pediatrics and is located in St. Louis Children's Hospital. Our faculty may specialize in Oncology, Hematology or both. Cell 2018 Jul 19 | WU Record 7/19/18, A multicenter clinical trial of a personalized vaccine has indicated improved survival rates in glioblastoma patients. Leukemia 2018 Apr 2 | WU Record 4/24/18, Researchers nationwide have reached a major milestone in describing the genetic landscape of cancer. Washington University has received a $3.7 million grant from the National Institutes of Health to support an open-source database aimed at boosting personalized approaches to cancer treatment. Clin Orthop Relat Res 2020 Dec;478(12):2812-2820, Voices on Diversity: Multiple Paths to Becoming a Scientist, Approaches to Aggressive B-Cell Lymphomas in Less Fit Patients, Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):140-147, Phosphorylation-Dependent Conformations of the Disordered Carboxyl-Terminus Domain in the Epidermal Growth Factor Receptor, J Phys Chem Lett 2020 Dec 3;11(23):10037-10044, BL-8040 CXCR4 Antagonist Is Safe and Demonstrates Antileukemic Activity in Combination With Cytarabine for the Treatment of Relapsed/Refractory Acute Myelogenous Leukemia: An Open-Label Safety and Efficacy Phase 2a Study, Multidimensional Analyses of Donor Memory-Like NK Cells Reveal New Associations With Response After Adoptive Immunotherapy for Leukemia, Expanding Dasatinib Beyond KIT in Acute Myeloid Leukemia, Haematologica 2020 Dec 1;105(12):2708-2710, Statins Reduce Mortality in Multiple Myeloma: A Population-Based US Study, Clin Lymphoma Myeloma Leuk 2020 Dec;20(12):e937-e943, A "Tail" of Immunotherapy in Metastatic Prostate Cancer, A Dose-Finding Phase 2 Study of Single Agent Isatuximab (Anti-CD38 MAb) in Relapsed/Refractory Multiple Myeloma, Hematopoietic Cell Transplantation Utilization and Outcomes for Primary Plasma Cell Leukemia in the Current Era, Barriers to Hematopoietic Cell Transplantation for Adults in the United States: A Systematic Review With a Focus on Age, Biol Blood Marrow Transplant 2020 Dec;26(12):2335-2345, A Pilot Study of Lenalidomide Maintenance Therapy After Autologous Transplantation in Relapsed or Refractory Classical Hodgkin Lymphoma, Biol Blood Marrow Transplant 2020 Dec;26(12):2223-2228, Integration of Physician and Nursing Professional Efforts to Deliver Supportive Scalp Cooling Care to Oncology Patients at Risk for Alopecia, Primary Refractory Multiple Myeloma: A Real-World Experience With 85 Cases, Atypical Fibroxanthoma: A Malignant Tumor of the Skin and Soft Tissue, J Am Acad Dermatol 2020 Dec;83(6):e429-e430, Racial and Ethnic Disparities in 21-Gene Recurrence Scores, Chemotherapy, and Survival Among Women With Hormone Receptor-Positive, Node-Negative Breast Cancer, Breast Cancer Res Treat 2020 Dec;184(3):915-925, Laparoscopic Cytoreductive Nephrectomy Is Associated With Significantly Improved Survival Compared With Open Cytoreductive Nephrectomy or Targeted Therapy Alone, SWOG S1400A (NCT02154490): A Phase II Study of Durvalumab for Patients With Previously Treated Stage IV or Recurrent Squamous Cell Lung Cancer (Lung-MAP Sub-Study), Clin Lung Cancer 2020 Nov 10; [Epub ahead of print], Metachronous Cutaneous Squamous Cell Carcinoma in a Young Patient as the Only Presenting Symptom to Uncover Lynch Syndrome With MLH1 Germline Mutation, Hered Cancer Clin Pract 2020 Nov 16;18(1):23, Cardio-Oncology Care in the Era of the Coronavirus Disease 2019 (COVID-19) Pandemic: An International Cardio-Oncology Society (ICOS) Statement, Implications of Pneumonitis After Chemoradiation and Durvalumab for Locally Advanced Non-Small Cell Lung Cancer, Tumor Microenvironment-Targeted Nanoparticles Loaded With Bortezomib and ROCK Inhibitor Improve Efficacy in Multiple Myeloma, Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy, Carfilzomib, Lenalidomide, and Dexamethasone Plus Transplant in Newly Diagnosed Multiple Myeloma, Endogenous and Combination Retinoids Are Active in Myelomonocytic Leukemias, Determining the Recommended Dose of Pacritinib: Results From the PAC203 Dose-Finding Trial in Advanced Myelofibrosis, A Randomized, Open-Label, Phase 2, Multicenter Trial of Gemcitabine With Pazopanib or Gemcitabine With Docetaxel in Patients With Advanced Soft-Tissue Sarcoma, Cancer 2020 Nov 24; [Epub ahead of print], Mutation Profile Differences in Younger and Older Patients With Advanced Breast Cancer Using Circulating Tumor DNA (ctDNA), Breast Cancer Res Treat 2020 Nov 20; [Epub ahead of print], A Phase 1b Study of AFM13 in Combination With Pembrolizumab in Patients With Relapsed or Refractory Hodgkin Lymphoma, A Cautionary Tale and Update on Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL), Aesthet Surg J 2020 Nov 19;40(12):1288-1300, Preferentially Expressed Antigen in Melanoma (PRAME) Expression in Malignant, but Not Benign, Peripheral Nerve Sheath Tumors, J Neuropathol Exp Neurol 2020 Nov 19; [Epub ahead of print], A Multi-Modal Diagnostic Model Improves Detection of Cardiac Amyloidosis Among Patients With Diagnostic Confirmation by Cardiac Biopsy, Am Heart J 2020 Nov 16; [Epub ahead of print], Final Results of a Phase 1 Study of Loncastuximab Tesirine in Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma, Inactivation of the Three GGA Genes in HeLa Cells Partially Compromises Lysosomal Enzyme Sorting, FEBS Open Bio 2020 Nov 18; [Epub ahead of print], Entinostat Plus Pembrolizumab in Patients With Metastatic NSCLC Previously Treated With Anti-PD-(L)1 Therapy, Clin Cancer Res 2020 Nov 17; [Epub ahead of print], The Landscape of Novel Therapeutics and Challenges in Glioblastoma Multiforme: Contemporary State and Future Directions, Pharmaceuticals (Basel) 2020 Nov 14;13(11), Longer Follow-Up Confirms Recurrence-Free Survival Benefit of Adjuvant Pembrolizumab in High-Risk Stage III Melanoma: Updated Results From the EORTC 1325-MG/KEYNOTE-054 Trial, J Clin Oncol 2020 Nov 20;38(33):3925-3936, Phase I Study of Liposomal Irinotecan in Patients With Metastatic Breast Cancer: Findings From the Expansion Phase, Breast Cancer Res Treat 2020 Nov 17; [Epub ahead of print], Clinical Challenges in the Management of Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer: A Literature Review, Adv Ther 2020 Nov 15; [Epub ahead of print], Facts and Hopes in Immunotherapy of Soft-Tissue Sarcomas, Clin Cancer Res 2020 Nov 15;26(22):5801-5808, CAR-Modified Memory-Like NK Cells Exhibit Potent Responses to NK-Resistant Lymphomas, In Vivo Tumorigenesis, Osteolytic Sarcomas, and Tumorigenic Cell Lines From Transgenic Mice Expressing the Human T-Lymphotropic Virus Type 1 (HTLV-1) Tax Viral Oncogene, Am J Pathol 2020 Nov 9; [Epub ahead of print], Crit Rev Biochem Mol Biol 2020 Nov 12:1-14, Development of [(89)Zr]DFO-Elotuzumab for ImmunoPET Imaging of CS1 in Multiple Myeloma, Eur J Nucl Med Mol Imaging 2020 Nov 11; [Epub ahead of print]. Walter, an international leader in the study and treatment of myelodysplastic syndromes (MDS), a group of rare blood disorders that prevents the body from making sufficient healthy blood cells, is a professor of medicine and director of the Edward P. Evans Center for Myelodysplastic Syndromes at the School of Medicine. Patients may benefit when indels are found in genes that already have drugs designed to counter the effects of mutation. After analyzing the complex metabolism of these tumors, Brian Van Tine, Jason Held, and co-workers discovered that adding a glutamine inhibitor to an arginine-depleting drug killed the cells and caused tumor regression in mice. Journal of Experimental Medicine 2017 Sep 5 | WU Record 9/5/17 | Outlook Magazine winter 2017/18, John DiPersio, Chief of the Division of Oncology, has received a $6 million outstanding investigator award from the National Cancer Institute (NCI) of the National Institutes of Health (NIH) to support research aimed at improving therapies for leukemia. The database, called CIViC, was designed by computational biologists Obi Griffith and Malachi Griffith. WU Record 7/30/19, In collaboration with investigators at Rush University in Chicago, David DeNardo and colleagues have found a chemical compound that promotes a vigorous immune assault against pancreatic cancer in mice. Luis Batista, Chris Sturgeon and co-workers used CRISPR to edit into human embryonic stem cells two mutations associated with the disease to produce a novel model of the disorder. Medical Oncology has also grown explosively over the past 10 years. Washington University oncologists at the Siteman Cancer Center devote their efforts to preventing, diagnosing and treating cancer. We have recruited 19 faculty who either trained at Washington University or trained here and were junior faculty members at other institutions prior to returning to Washington University. To make an appointment at Siteman Cancer Center, call 800-647-2098. Hematology & Oncology We diagnose and offer innovative treatments for nearly every type of solid tumor cancer of the head & neck, breast, lung, pancreas, liver, kidney, prostate and reproductive system. Our program has performed over 5,000 bone marrow and stem cell transplants since its inception, making it one of the top five programs in the country. Many are involved in “translational research”, meaning they conduct research studies, enabling many new treatments to be available as […] The Washington University SPORE, led by Dan Link is one of only three academic centers in the U.S. to receive this grant. The group presently has five medical Hematologists Oncologists and support staff of Laboratory technicians, pharmacy technicians, phlebotomists, and Oncology Nurses. The combined faculty in both divisions numbered only eight, two in BMT and six in Medical Oncology. Studying mice, the researchers found the drug prevented graft-versus-host disease, a debilitating, sometimes lethal condition that develops when transplanted stem cells attack the body’s own organs or tissues. Jeff Ward and Chris Miller are members of a global consortium that has identified features of tumor neoantigens that trigger T cells to attack the cancer and leave healthy tissue untouched. CD123 Bi-Specific Antibodies in Development in AML: What Do We Know So Far? WU Record 7/10/20, Matthew J. Walter, MD, has been named the inaugural Edward P. Evans Endowed Professor at Washington University School of Medicine. We are proud that many of our past fellows have gone on to very successful clinical and research careers within our program and at other academic institutions. Education and Fellowship Training . The Hematology-Oncology Fellowship Training Program at the University of Washington is designed to develop academic physicians who are competent in clinical hematology/oncology and research. WU Record 5/18/16, Ramaswamy Govindan has been named the Anheuser-Busch Endowed Chair in Medical Oncology. Cancer Research 2017 Aug 30 | WU Record 9/25/17, Children with dyskeratosis congenita - characterized by short telomeres - experience progressive bone marrow failure, eventually losing the ability to make red blood cells, white blood cells and platelets. Nature Genetics 2017 Jan 31 | WU Record 1/30/17, Many sarcomas lack an enzyme required for production of arginine, an essential component of most proteins, but attempts to kill the tumor cells by starving them of this nutrient have been unsuccessful. Of the 1,200 new patients placed on therapeutic clinical trials in the past year in the Siteman Cancer Center, the Oncology Division was responsible for over 1,050 accruals. The strategy, developed in mouse studies, lets chemotherapy penetrate the protective environment of bone and minimizes toxic side effects. WU Record 9/25/19, Mark Sands and his colleagues have discovered the precise biochemical pathway leading to Krabbe disease, a fatal genetic disorder in children that results in seizures, developmental regression and death, usually around age 3. WU Record 9/11/19, A team of Washington University investigators led by Tim Ley have been awarded a $15 million NIH grant to better understand the genetic changes that drive acute myeloid leukemia and predict patients’ responses to therapy. Division of Medical Oncology, Department of Mecicine, University of Washington . Our faculty include physicians and scientists who work on all forms of cancer and who are part of a larger community of scientists at the University of Washington and Fred Hutchinson Cancer Research Center. J Dermatol 2020 Nov 7; [Epub ahead of print], A Phase I Trial of Temsirolimus and Erlotinib in Patients With Refractory Solid Tumors, Cancer Chemother Pharmacol 2020 Nov 6; [Epub ahead of print], Outcomes of Patients With Large B-Cell Lymphoma Progressing After Axicabtagene Ciloleucel, Cardio-Oncology Education and Training: JACC Council Perspectives, J Am Coll Cardiol 2020 Nov 10;76(19):2267-2281, Tolerability and Safety of EUS-Injected Adenovirus-Mediated Double-Suicide Gene Therapy With Chemotherapy in Locally Advanced Pancreatic Cancer: A Phase 1 Trial, Gastrointest Endosc 2020 Nov;92(5):1044-1052, TGF-Beta Suppresses Type 2 Immunity to Cancer, Tazemetostat in Advanced Epithelioid Sarcoma With Loss of INI1/SMARCB1: An International, Open-Label, Phase 2 Basket Study, Phase I Basket Study of Taselisib, an Isoform-Selective PI3K Inhibitor, in Patients With PIK3CA-Mutant Cancers, Clin Cancer Res 2020 Nov 4; [Epub ahead of print], NCCN Guidelines Insights: T-Cell Lymphomas, Version 1.2021, J Natl Compr Canc Netw 2020 Nov 2;18(11):1460-1467, Central Nervous System Cancers, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology, J Natl Compr Canc Netw 2020 Nov 2;18(11):1537-1570, Discovery of Driver Non-Coding Splice-Site-Creating Mutations in Cancer, Integration of Genomic Medicine in Pathology Resident Training, Am J Clin Pathol 2020 Nov 4;154(6):784-791, Safety and Efficacy of Vorinostat Plus Sirolimus or Everolimus in Patients With Relapsed Refractory Hodgkin Lymphoma, Clin Cancer Res 2020 Nov 1;26(21):5579-5587, Multi-Institutional Prospective Validation of Prognostic mRNA Signatures in Early Stage Squamous Lung Cancer (Alliance). WU Record 1/9/19, Their gift establishes the Paula C. and Rodger O. Riney Blood Cancer Research Initiative Fund to develop promising new treatments for multiple myeloma. By studying this group of patients, the investigators hope to understand the differences between those patients who go on to develop MDS and those who don’t. Department of Radiation Oncology Mailing Address: 660 S. Euclid Ave, Campus Box 8224 | St. Louis, MO 63110 Phone: 314-362-9700 Siteman Cancer Center at the Center for Advanced Medicine Office Location: 4921 Parkview Pl, Lower Level | St. Louis, MO 63110 Phone: 314-747-7236 The aim is to better reflect the spectrum of human diversity around the world and make the reference genome a more useful tool for researchers. It was the vision of the late Dr. Stanley Korsmeyer (June 8, 1951 - March 31, 2005) who sought to expand both clinical and translational programs in hematologic and solid tumor malignancies at Washington University School of Medicine. Homologous Recombination Deficiency Real-Time Clinical Assays, Ready or Not? The knowledge could help guide treatment decisions. Submissions are curated by editors and moderators who are experts in the field. Hematology and Medical Oncology Best Practices Course Accreditation The George Washington University School of Medicine and Health Sciences is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. They showed how blocking the downstream effects of these mutations can lead to normal production of blood cells. Hematology, medical oncology - Specialty services provided by Washington University Physicians in Illinois, Inc. Education 1971: MD, St. Louis University School of Medicine Each section is led by world class and internationally recognized experts including Tim Ley, MD (Stem Cell Biology); Lee Ratner, MD, PhD (Molecular Oncology); Matthew Ellis, MD, PhD (Medical Oncology); and Peter Westervelt MD, PhD (BMT & Leukemia). For additional information on the Hematology/Oncology Fellowship Program, please contact: Adrian Hameed, Fellowship Administrator MedStar Georgetown University Hospital Division of Hematology/Oncology 3800 Reservoir Road, NW LCCC, 2nd floor Podium B Washington, DC 20007. It was the vision of the late Dr. Stanley Korsmeyer (June 8, 1951 - March 31, 2005) who sought to expand both clinical and translational programs in hematologic and solid tumor malignancies at Washington University School of Medicine. Science Translational Medicine 2016 Sep 21 | WU Record 9/21/16, The level of an RNA molecule (PCAT-14) expressed in prostate tumors is an indicator of whether the cancer is likely to spread, according to research published by Chris Maher and colleagues. A fourth SCC outpatient office in South County will be open soon. Led by Li Ding and colleagues in the Departments of Surgery and Radiology, the research will focus on how breast cancer evolves in response to treatments and how some tumors develop resistance to these treatments. In fact, members of the Division of Oncology, in collaboration with members of the Washington University Genome Center, were the first to complete the full DNA sequences of the first cancer genomes for patients with acute myelogenous leukemia (Ley, Nature 2008) and breast cancer (Ellis, Nature 2010). Nature Communications 2018 Sep 4 | WU Record 9/14/18, Using genetic sequencing, scientists have revealed the complete DNA makeup of more than 100 aggressive prostate tumors, pinpointing important genetic errors these deadly tumors have in common. But new research by John Welch and colleagues in the Oncology Division indicates that such patients, paradoxically, may live longer if they receive a milder chemotherapy drug. These include two clinical/translational research sections (BMT & Leukemia and Medical Oncology) and two basic science sections (Stem Cell Biology and Molecular Oncology). There are now over 25 faculty who subspecialize in every cancer type from neuro-oncology to breast, gastro-intestinal, genito-urinary, and thoracic oncology. WU Record 2/17/16, Li Ding and co-workers developed a software tool for finding a certain type of genetic error that has been consistently missed by cancer genome studies. 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